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His Holiness the Karmapa talks about how he was discovered to be the reincarnation of a revered figure in Tibetan Buddhism. In telling his story, he urges us to work on not just technology and design, but the technology and design of the heart. He is translated onstage by Tyler Dewar.

Human growth has strained the Earth's resources, but as Johan Rockstrom reminds us, our advances also give us the science to recognize this and change behavior. His research has found nine "planetary boundaries" that can guide us in protecting our planet's many overlapping ecosystems.

Statistician Nic Marks asks why we measure a nation's success by its productivity -- instead of by the happiness and well-being of its people. He introduces the Happy Planet Index, which tracks national well-being against resource use (because a happy life doesn't have to cost the earth). Which countries rank highest in the HPI? You might be surprised.

Physics and marketing don't seem to have much in common, but Dan Cobley is passionate about both. He brings these unlikely bedfellows together using Newton's second law, Heisenberg's uncertainty principle, the scientific method and the second law of thermodynamics to explain the fundamental theories of branding.

In the Gulf oil spill's aftermath, Lisa Margonelli says drilling moratoriums and executive ousters make for good theater, but distract from the issue at its heart: our unrestrained oil consumption. She shares her bold plan to wean America off of oil -- by confronting consumers with its real cost.

Cartoonist Jim Toomey created the comic strip Sherman's Lagoon, a wry look at underwater life starring Sherman the talking shark. As he sketches some of his favorite sea creatures live onstage, Toomey shares his love of the ocean and the stories it can tell.

Science columnist Lee Hotz describes a remarkable project at WAIS Divide, Antarctica, where a hardy team are drilling into ten-thousand-year-old ice to extract vital data on our changing climate.

David McCandless turns complex data sets (like worldwide military spending, media buzz, Facebook status updates) into beautiful, simple diagrams that tease out unseen patterns and connections. Good design, he suggests, is the best way to navigate information glut -- and it may just change the way we see the world.

By now, we're used to letting Facebook and Twitter capture our social lives on the web -- building a "social layer" on top of the real world. At TEDxBoston, Seth Priebatsch looks at the next layer in progress: the "game layer," a pervasive net of behavior-steering game dynamics that will reshape education and commerce.

A founding member of the Axis of Evil Comedy Tour, standup comic Maz Jobrani riffs on the challenges and conflicts of being Iranian-American -- "like, part of me thinks I should have a nuclear program; the other part thinks I can't be trusted ..."

Jamil Abu-Wardeh jump-started the comedy scene in the Arab world by founding the Axis of Evil Middle East Comedy Tour, which brings standup comedians to laughing audiences all over the region. He's found that, by respecting the "three B's" (blue material, beliefs and "bolitics"), the Axis of Evil comics find plenty of cross-border laughs.

Peter Molyneux demos Milo, a hotly anticipated video game for Microsoft's Kinect controller. Perceptive and impressionable like a real 11-year-old, the virtual boy watches, listens and learns -- recognizing and responding to you.

Sheryl WuDunn's book "Half the Sky" investigates the oppression of women globally. Her stories shock. Only when women in developing countries have equal access to education and economic opportunity will we be using all our human resources.

Convince just 100 key companies to go sustainable, and WWF's Jason Clay says global markets will shift to protect the planet our consumption has already outgrown. Hear how his extraordinary roundtables are getting big brand rivals to agree on green practices first -- before their products duke it out on store shelves.

After he swam the North Pole, Lewis Pugh vowed never to take another cold-water dip. Then he heard of Lake Imja in the Himalayas, created by recent glacial melting, and Lake Pumori, a body of water at an altitude of 5300 m on Everest -- and so began a journey that would teach him a radical new way to approach swimming and think about climate change.

Laurie Santos looks for the roots of human irrationality by watching the way our primate relatives make decisions. A clever series of experiments in "monkeynomics" shows that some of the silly choices we make, monkeys make too.

Oceanographer John Delaney is leading the team that is building an underwater network of high-def cameras and sensors that will turn our ocean into a global interactive lab -- sparking an explosion of rich data about the world below.

Break down the oil slick, keep it off the shores: that's grounds for pumping toxic dispersant into the Gulf, say clean-up overseers. Susan Shaw shows evidence it's sparing some beaches only at devastating cost to the health of the deep sea.

Sheena Iyengar studies how we make choices -- and how we feel about the choices we make. At TEDGlobal, she talks about both trivial choices (Coke v. Pepsi) and profound ones, and shares her groundbreaking research that has uncovered some surprising attitudes about our decisions.

Arthritis and injury grind down millions of joints, but few get the best remedy -- real biological tissue. Kevin Stone shows a treatment that could sidestep the high costs and donor shortfall of human-to-human transplants with a novel use of animal tissue.